The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504

Chemistry & Chemical Technology

Authors

First and Last Name Academic degree E-mail Affiliation
Sofiia Melnyk No sofiamelnyk [at] gmail.com Ivan Franko National University of Lviv
Lviv, Ukraine
Bohdan Ostash Sc.D. bohdan.ostash [at] lnu.edu.ua Ivan Franko National University of Lviv
Lviv, Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 02.11.2018 - 09:05
Abstract

Clorobiocin is potent aminocoumarin against resistant pathogens. We describe attempts to improve clorobiocin production via expression of pleiotropic (adpA) and pathway-specific regulatory (cloG, novG) genes in Streptomyces roseochromogenes NRRL3504. Positive influence of adpA on clorobiocin production was revealed. The effects of cloG and novG are under investigation.

References

[1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. “Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics”. J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011.

[2] F. Pojer, S.M. Li, and L. Heide. “Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics”. Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002.

[3] L. Heide. “The aminocoumarins: biosynthesis and biology”. Nat. Prod. Rep., vol. 26, no. 10,  pp. 1241-1250, 2009.

[4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. “Molecular regulation of antibiotic biosynthesis in streptomyces”. Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013.

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Secretary CCT
researcher, secretary

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Your paper has been accepted!

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Thu, 11/15/2018 - 00:03
Sofiia Melnyk
researcher

1. Yes, I am going to take part in person.

2. Yes, I require official invitation letter.

Thu, 11/15/2018 - 22:27