The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504
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Clorobiocin is potent aminocoumarin against resistant pathogens. We describe attempts to improve clorobiocin production via expression of pleiotropic (adpA) and pathway-specific regulatory (cloG, novG) genes in Streptomyces roseochromogenes NRRL3504. Positive influence of adpA on clorobiocin production was revealed. The effects of cloG and novG are under investigation.
[1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. “Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics”. J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011.
[2] F. Pojer, S.M. Li, and L. Heide. “Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics”. Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002.
[3] L. Heide. “The aminocoumarins: biosynthesis and biology”. Nat. Prod. Rep., vol. 26, no. 10, pp. 1241-1250, 2009.
[4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. “Molecular regulation of antibiotic biosynthesis in streptomyces”. Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013.
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1. Yes, I am going to take part in person.
2. Yes, I require official invitation letter.