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  4. Design of Hydrogenated Isoindolylalkyl(Alkaryl-, Aryl-)Carboxylic Acids with Quinazoline Fragment, that Modify the Carbohydrate Metabolism

Design of Hydrogenated Isoindolylalkyl(Alkaryl-, Aryl-)Carboxylic Acids with Quinazoline Fragment, that Modify the Carbohydrate Metabolism

Chemistry & Chemical Technology
Proceedings of the 8th International Youth Science Forum "Litteris et Artibus", November 22–24, 2018, Lviv: Lviv Polytechnic National University, 2018, pp. 155–157

DOI: https://doi.org/10.23939/lea2018.01.155

Authors

First and Last Name Academic degree E-mail Affiliation
Yulya Martynenko Ph.D. martynenkou20 [at] gmail.com Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University
Zaporizhzhya, Ukraine
Oleksii Antypenko Sc.D. antypenkoan [at] gmail.com Organic and Bioorganic Chemistry Department, Zaporizhzhya State Medical University
Zaporizhzhya, Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 30.10.2018 - 15:28
Abstract

Fragment-oriented design, namely molecular docking of N-carboxyalkyl-(aralkyl-, aryl-)-isoindoline-1,3-diones’ (3H-quinazoline-4-ylidene)hydrazides and 2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-, aryl-)-hydroisoindole-1,3(2H)-diones allowed to reveal substances that modify the carbohydrate metabolism. The results of pharmacological screening revealed several compounds, which are short-acting hypoglycemic agents like prandial regulators of glucose (Mitiglinide).

Keywords
(3Н-quinazoline-4-ylidene)hydrazides of N-carboxyalkyl-(aralkyl-aryl-)-isoindoline-1,3-diones2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-aryl-)-hydroisoindole-1,3(2H)-dionesdesigndocking studieshypoglycemic activity
References

[1]  RSCB Protein Data Bank. [Online]. Available: https://www.rcsb.org [Accessed 24 Oct 2018].

[2]  MarvinSketch version: 17.21.0, ChemAxon. [Online]. Available: https://chemaxon.com/products/marvin [Accessed 24 Oct 2018].

[3]  O. Trott and A.J. Olson, “AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading,” Journal of Computitaonal Chemistry, vol. 31, 2010, pp. 455-461.

[4]  S. Kovalenko et al., “Synthesis and anticancer activity of 2-(alkyl-, alkaryl-, aryl-, hetaryl-)-[1,2,4]triazolo[1,5-c]quinazolines,” Scientia Pharmaceutica, vol. 81 (2), 2013, pp. 359-392.

First published Full Text (30.10.2018 - 15:28)
Official paper

Comments

Secretary CCT
researcher, secretary

Dear autors,

Your paper has been accepted!

We are glad to inform you that your conference paper has been accepted to participate in the 8th International Joint Youth Science Forum «Litteris et Artibus» & 13th International Conference «Young Scientists Towards the Challenges of Modern Technology», particularly in «Chemistry & Chemical Technology» (CCT) conference (November 22-24, 2018, Lviv, Ukraine)! Your paper will be published in digital proceedings with ISSN and DOI on the website https://openreviewhub.org/lea-2018.

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Одержувач: Первинна профспілкова організація студентів та аспірантів Національного університету «Львівська політехніка»

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Looking forward to receiving your poster! See you in Lviv soon!

Best regards,

Oksana Orobchuk,

Secretary CCT

Thu, 11/15/2018 - 00:05