Particles and lungs - where chemical engineering meets medicine
Computer simulation in the chemical technology and engineering
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 30–35
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First published on this website: 06.05.2019 - 11:42
Abstract
Paper draws attention to chemical engineering applications in the problems of drug delivery by inhalation, i.e. in atomization of liquids, preparation of functional powders and their aerosolization, aerodynamic design of inhaling devices, and finally – flow and mass transfer processes in the layers of lung fluids (bronchial mucus and pulmonary surfactant).
References
[1] A.J. deMello, “Control and detection of chemical reactions in microfluidic systems,” Nature, vol. 442, pp. 394–402, 2006.
[2] I. Gonda, “Systemic delivery of drugs to humans via inhalation,” J. Aerosol Med., vol. 19, pp. 47-53, 1996.
[3] T.R. Sosnowski, “Selected engineering and physicochemical aspects of systemic drug delivery by inhalation,” Curr. Pharm. Des., vol. 22, pp. 2453-2462, 2016.
[4] O.N.M. McCallion, K.M. Taylor, M. Thomas, A.J. Taylor, “Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers,” Pharm. Res., vol. 12, pp. 1682-1688, 1995.
[5] L. Broniarz-Press, T.R. Sosnowski, M. Matuszak, M. Ochowiak, K. Jabłczyńska, “The effect of shear and extensional viscosities on atomization of Newtonian and non-Newtonian fluids in ultrasonic inhaler,” Int. J. Pharmaceutics, vol. 485, pp. 41-49, 2015.
[6] M. Beck-Broichsitter, “Aerosol production by vibrating membrane technology: analysis of the electrolyte effect on generated droplet size and nebulizer output rate,” J. Pharm. Sci., vol. 106, pp. 2168-2172, 2017.
[7] T.R. Sosnowski, “Inhaled steroids delivered by mesh nebulizers – what should we know?,” Terapia, vol. 3s/2019, pp. 1-6, 2019.
[8] M. Pirożyński, T.R. Sosnowski, “Inhalation devices: from basic science to practical use, innovative vs generic products,” Expert Opin. Drug Del., vol. 13, pp. 1559-1571, 2016.
[9] K. Kramek-Romanowska, M. Odziomek, T.R. Sosnowski, L. Gradoń, “Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation,” Ind. Eng. Chem. Res., vol. 50, pp. 13922-13931, 2011.
[10] M. Odziomek, T.R. Sosnowski, L. Gradoń, “Conception, preparation and properties of functional carrier particles for pulmonary drug delivery,” Int J. Pharmaceutics, vol. 433, pp. 51-59, 2012.
[11] L. Gradoń, T.R. Sosnowski, “Formation of particles for dry powder inhalers,” Adv. Powder Technol., vol. 25, pp. 43-55, 2014.
[12] K. Jabłczyńska, M. Janczewska, A. Kulikowska, T.R. Sosnowski, “Preparation and characterization of biocompatible polymer particles as potential nanocarriers for inhalation therapy,” Int J. Polymer Sci., vol. 1, pp. 1-8, 2015.
[13] K. Jabłczyńska, J.M. Gac, T.R. Sosnowski, “Self-organization of colloidal particles during drying of a droplet: modeling and experimental study,” Adv. Powder Technol., vol. 29, pp. 3542-3551, 2018.
[14] M. Odziomek, T.R. Sosnowski, L. Gradoń, “The influence of functional carrier particles (FCPs) on the molecular transport rate through the reconstructed bronchial mucus - in vitro studies,” Transport in Porous Media, vol. 106, pp. 439-454, 2015.
[15] K. Kramek-Romanowska, M. Odziomek, T.R. Sosnowski, “Dynamic tensiometry studies on interactions of novel therapeutic inhalable powders with model pulmonary surfactant at the air-water interface,” Colloids Surfaces A: Physicochem. Eng. Aspects, vol. 480, pp. 149-158, 2015.
[16] T.R. Sosnowski, “Particles on the lung surface – physicochemical and hydrodynamic effects,” Curr. Opin. Colloid Interface Sci., vol. 36, pp. 1-9, 2018.
[17] A. Hejduk, A. Urbańska, A. Osiński, P. Łukaszewicz, M. Domański, T.R. Sosnowski, “Technical challenges in obtaining an optimized powder/DPI combination for inhalation delivery of a bi-component generic drug,” J. Drug Deliv. Sci. Technol., vol. 44, pp. 406-414, 2018.
[18] J. Gac, T.R. Sosnowski, L. Gradoń, “Turbulent flow energy for aerosolization of powder particles,” J. Aerosol Sci., vol. 39, pp. 113-126, 2008.
[19] T.R. Sosnowski, K. Giżyńska, Ł. Żywczyk, “Fluidization and break-up of powder particle aggregates during constant and pulsating flow in converging nozzles,” Colloids Surfaces A: Physicochem. Eng. Aspects, vol. 441, pp. 905-911, 2014.
[20] T.R. Sosnowski, L. Gradoń, M. Skoczek, H. Droździel, “Experimental evaluation of the importance of the pulmonary surfactant for oxygen transfer rate in human lungs,” Int. J. Occup. Safety Ergon., vol.4, pp. 391-409, 1998.
[21] T.R. Sosnowski, A. Podgórski, L. Gradoń, “Influence of insoluble aerosol deposits on the surface activity of the pulmonary surfactant: a possible mechanism of alveolar clearance retardation?,” Aerosol Sci. Techn., vol. 32, pp. 52-60, 2000.
[22] D. Kondej, T.R. Sosnowski, “Effect of clay nanoparticles on model lung surfactant: a potential marker of hazard from nanoaerosol inhalation,” Environ. Sci. Pollut. Res., vol. 23, pp. 4660-4669, 2016.
[23] T.R. Sosnowski, L. Gradoń, “Modification of inhalable powders by pulmonary surfactant components adsorbed on droplets during spray-drying process,” Colloids Surfaces A: Physicochem. Eng. Aspects, vol.365, pp. 56-61, 2010.
[24] K. Dobrowolska, T.R. Sosnowski, “Deposition and interaction of inhalation drugs with the lung surface – model studies,” Inż. Aparat Chem., vol. 57, no. 3, pp. 53-54, 2018.
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