Particles and lungs - where chemical engineering meets medicine

Computer simulation in the chemical technology and engineering
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 30–35

Authors

First and Last Name Academic degree E-mail Affiliation
Tomasz Sosnowski Sc.D. tomasz.sosnowski [at] pw.edu.pl Faculty of Chemical and Process Engineering, Warsaw University of Technology
Warsaw, Poland

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First publshed on this website: 06.05.2019 - 11:42
Abstract

Paper draws attention to chemical engineering applications in the problems of drug delivery by inhalation, i.e. in atomization of liquids, preparation of functional powders and their aerosolization, aerodynamic design of inhaling devices, and finally – flow and mass transfer processes in the layers of lung fluids (bronchial mucus and pulmonary surfactant).

References

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[5] L. Broniarz-Press, T.R. Sosnowski, M. Matuszak, M. Ochowiak, K. Jabłczyńska, “The effect of shear and extensional viscosities on atomization of Newtonian and non-Newtonian fluids in ultrasonic inhaler,” Int. J. Pharmaceutics, vol. 485, pp. 41-49, 2015.

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[13] K. Jabłczyńska, J.M. Gac, T.R. Sosnowski, “Self-organization of colloidal particles during drying of a droplet: modeling and experimental study,” Adv. Powder Technol., vol. 29, pp. 3542-3551, 2018.

[14] M. Odziomek, T.R. Sosnowski, L. Gradoń, “The influence of functional carrier particles (FCPs) on the molecular transport rate through the reconstructed bronchial mucus - in vitro studies,” Transport in Porous Media, vol. 106, pp. 439-454, 2015.

[15] K. Kramek-Romanowska, M. Odziomek, T.R. Sosnowski, “Dynamic tensiometry studies on interactions of novel therapeutic inhalable powders with model pulmonary surfactant at the air-water interface,” Colloids Surfaces A: Physicochem. Eng. Aspects, vol. 480, pp. 149-158, 2015.

[16] T.R. Sosnowski, “Particles on the lung surface – physicochemical and hydrodynamic effects,” Curr. Opin. Colloid Interface Sci., vol. 36, pp. 1-9, 2018.

[17] A. Hejduk, A. Urbańska, A. Osiński, P. Łukaszewicz, M. Domański, T.R. Sosnowski, “Technical challenges in obtaining an optimized powder/DPI combination for inhalation delivery of a bi-component generic drug,” J. Drug Deliv. Sci. Technol., vol. 44, pp. 406-414, 2018.

[18] J. Gac, T.R. Sosnowski, L. Gradoń, “Turbulent flow energy for aerosolization of powder particles,” J. Aerosol Sci., vol. 39, pp. 113-126, 2008.

Official paper