Particles and lungs - where chemical engineering meets medicine

Computer simulation in the chemical technology and engineering
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 30–35


First and Last Name Academic degree E-mail Affiliation
Tomasz Sosnowski Sc.D. tomasz.sosnowski [at] Faculty of Chemical and Process Engineering, Warsaw University of Technology
Warsaw, Poland

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 06.05.2019 - 11:42

Paper draws attention to chemical engineering applications in the problems of drug delivery by inhalation, i.e. in atomization of liquids, preparation of functional powders and their aerosolization, aerodynamic design of inhaling devices, and finally – flow and mass transfer processes in the layers of lung fluids (bronchial mucus and pulmonary surfactant).


[1] A.J. deMello, “Control and detection of chemical reactions in microfluidic systems,” Nature, vol. 442, pp. 394–402, 2006.

[2] I. Gonda, “Systemic delivery of drugs to humans via inhalation,” J. Aerosol Med., vol. 19, pp. 47-53, 1996.

[3] T.R. Sosnowski, “Selected engineering and physicochemical aspects of systemic drug delivery by inhalation,” Curr. Pharm. Des., vol. 22, pp. 2453-2462, 2016.

[4] O.N.M. McCallion, K.M. Taylor, M. Thomas, A.J. Taylor, “Nebulization of fluids of different physicochemical properties with air-jet and ultrasonic nebulizers,” Pharm. Res., vol. 12, pp. 1682-1688, 1995.

[5] L. Broniarz-Press, T.R. Sosnowski, M. Matuszak, M. Ochowiak, K. Jabłczyńska, “The effect of shear and extensional viscosities on atomization of Newtonian and non-Newtonian fluids in ultrasonic inhaler,” Int. J. Pharmaceutics, vol. 485, pp. 41-49, 2015.

[6] M. Beck-Broichsitter, “Aerosol production by vibrating membrane technology: analysis of the electrolyte effect on generated droplet size and nebulizer output rate,” J. Pharm. Sci., vol. 106, pp. 2168-2172, 2017.

[7] T.R. Sosnowski, “Inhaled steroids delivered by mesh nebulizers – what should we know?,” Terapia, vol. 3s/2019, pp. 1-6, 2019.

[8] M. Pirożyński, T.R. Sosnowski, “Inhalation devices: from basic science to practical use, innovative vs generic products,” Expert Opin. Drug Del., vol. 13, pp. 1559-1571, 2016.

[9] K. Kramek-Romanowska, M. Odziomek, T.R. Sosnowski, L. Gradoń, “Effects of process variables on the properties of spray-dried mannitol and mannitol/disodium cromoglycate powders suitable for drug delivery by inhalation,” Ind. Eng. Chem. Res., vol. 50, pp. 13922-13931, 2011.

[10] M. Odziomek, T.R. Sosnowski, L. Gradoń, “Conception, preparation and properties of functional carrier particles for pulmonary drug delivery,” Int J. Pharmaceutics, vol. 433, pp. 51-59, 2012.

[11] L. Gradoń, T.R. Sosnowski, “Formation of particles for dry powder inhalers,” Adv. Powder Technol., vol. 25, pp. 43-55, 2014.

[12] K. Jabłczyńska, M. Janczewska, A. Kulikowska, T.R. Sosnowski, “Preparation and characterization of biocompatible polymer particles as potential nanocarriers for inhalation therapy,” Int J. Polymer Sci., vol. 1, pp. 1-8, 2015.

[13] K. Jabłczyńska, J.M. Gac, T.R. Sosnowski, “Self-organization of colloidal particles during drying of a droplet: modeling and experimental study,” Adv. Powder Technol., vol. 29, pp. 3542-3551, 2018.

[14] M. Odziomek, T.R. Sosnowski, L. Gradoń, “The influence of functional carrier particles (FCPs) on the molecular transport rate through the reconstructed bronchial mucus - in vitro studies,” Transport in Porous Media, vol. 106, pp. 439-454, 2015.

[15] K. Kramek-Romanowska, M. Odziomek, T.R. Sosnowski, “Dynamic tensiometry studies on interactions of novel therapeutic inhalable powders with model pulmonary surfactant at the air-water interface,” Colloids Surfaces A: Physicochem. Eng. Aspects, vol. 480, pp. 149-158, 2015.

[16] T.R. Sosnowski, “Particles on the lung surface – physicochemical and hydrodynamic effects,” Curr. Opin. Colloid Interface Sci., vol. 36, pp. 1-9, 2018.

[17] A. Hejduk, A. Urbańska, A. Osiński, P. Łukaszewicz, M. Domański, T.R. Sosnowski, “Technical challenges in obtaining an optimized powder/DPI combination for inhalation delivery of a bi-component generic drug,” J. Drug Deliv. Sci. Technol., vol. 44, pp. 406-414, 2018.

[18] J. Gac, T.R. Sosnowski, L. Gradoń, “Turbulent flow energy for aerosolization of powder particles,” J. Aerosol Sci., vol. 39, pp. 113-126, 2008.

[19] T.R.  Sosnowski,  K.  Giżyńska, Ł. Żywczyk,  “Fluidization  and  break-up  of  powder  particle  aggregates  during  constant  and  pulsating  flow  in  converging  nozzles,”  Colloids  Surfaces  A: Physicochem. Eng. Aspects, vol. 441, pp. 905-911, 2014.

[20] T.R.  Sosnowski,  L.  Gradoń,  M.  Skoczek,  H.  Droździel,  “Experimental  evaluation  of  the  importance  of  the  pulmonary  surfactant  for  oxygen  transfer  rate  in  human  lungs,”  Int.  J.  Occup. Safety Ergon., vol.4, pp. 391-409, 1998.

[21] T.R.  Sosnowski,  A.  Podgórski,  L.  Gradoń,  “Influence  of  insoluble  aerosol  deposits  on  the  surface  activity  of  the  pulmonary  surfactant:  a  possible  mechanism  of  alveolar  clearance  retardation?,” Aerosol Sci. Techn., vol. 32, pp. 52-60, 2000.

[22] D.  Kondej,  T.R.  Sosnowski,  “Effect  of  clay  nanoparticles  on  model  lung  surfactant:  a  potential  marker  of  hazard  from  nanoaerosol  inhalation,”  Environ.  Sci.  Pollut.  Res.,  vol.  23, pp. 4660-4669, 2016.

[23] T.R.  Sosnowski,  L.  Gradoń,  “Modification  of  inhalable  powders  by  pulmonary  surfactant  components  adsorbed  on  droplets  during  spray-drying  process,”  Colloids  Surfaces  A:  Physicochem. Eng. Aspects, vol.365, pp. 56-61, 2010.

[24] K. Dobrowolska, T.R. Sosnowski, “Deposition and interaction of inhalation drugs with the lung surface – model studies,” Inż. Aparat Chem., vol. 57, no. 3, pp. 53-54, 2018.  

Official paper