Synthesis and antimicrobial activity of novel 2,4-disubstituted thiazoles

Green chemistry
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 249–250

DOI: https://doi.org/10.23939/cte2019.01.249

Authors

First and Last Name Academic degree E-mail Affiliation
Birutė Grybaitė Ph.D. birute.grybaite [at] ktu.edu Kaunas University of Technology
Kaunas, Lithuania
Rita Vaickelionienė Ph.D. vymic [at] ktu.lt Kaunas University of Technology
Kaunas, Lithuania
Vytautas Mickevičius Sc.D. vytautas.mickevicius [at] ktu.lt Kaunas University of Technology
Kaunas , Lithuania
Volodymyr Novikov Sc.D. volodymyr.p.novikov [at] lpnu.ua Lviv Polytechnic National University
Lviv , Ukraine
Viktor Zvarych Ph.D. maryna.v.stasevych [at] lpnu.ua Lviv Polytechnic National University
Lviv, Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 15.03.2019 - 14:03
Abstract

A beneficial modifications of 2-substituted thiazoles by incorporating different functional groups into the structure such as carboxyl, chloromethyl, (phenylamino)methyl, ethoxyoxoethyl, which determine a certain chemical reactions of the compound was developed. All the synthesized compounds were tested for their in vitro antimicrobial and antifungal activity.

Keywords
amino acidsantimicrobial agentscyclizationfunctionalized thiazolesreactive intermediates
References

[1] M. V. J. Nora de Souza, “Synthesis and biological activity of natural thiazoles: An important class of heterocyclic compounds”, Sulfur Chem., vol. 26, no. 4–5, , pp. 429-449, Aug.–Oct. 2005.

[2] P. K. Sasmal, S. Sridhar, J. Idbal, “Facile synthesis of thiazoles via an intramolecular thia-Michael strategy”, Tetrahedron Lett., vol. 47, iss. 49, Dec., pp. 8661-8665, 2006.

[3] B. Grybaitė, R. Vaickelionienė, M. Stasevych, o. Komarovska-Porokhnyavets, V. Novikov, V. Mickevičius, „Synthesis, Transformation of 3-[(4-Arylthiazol-2-yl)(ptolyl) amino]propanoic Acids, Bis(thiazol-5-yl)phenyl-, Bis(thiazol-5-yl)methane Derivatives, and Their Antimicrobial Activity“, Heterocycles, vol. 96, no. 1, pp. 86–105, Dec. 2018.

[4] Y. K. Abhale, A. Shinde, K. K. Deshmukh, L. Nawale, D. Sarkar, P. C. Mhask, “Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives”, Med. Chem. Res., vol. 26, iss. 10, pp. 2557-2567, Oct. 2017.

[5] T. I. de Santana, M. O. Barbosa, P. A. T. M. Gomes, A. C. N da Cruz , T. G. da Silva, A. C. L. Leite, “Synthesis, anticancer activity and mechanism of action of new thiazole derivatives”, Eur. J. Med. Chem., vol. 144, pp. 874-886, Jan. 2018.

First published Full Text (15.03.2019 - 14:03)
Official paper