Antibacterial activity studies of pyrazole derivatives – products of isoflavones recyclization
I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license
We have established that the recyclization of isocoumarins via 2-hydroxydesoxybenzon-2’-carboxylic acid amides and their subsequent reaction with DMFDMA is an efficient synthetic approach to previously difficult to obtain isoflavones with an amide function. The subsequent recyclization of isoflavones resulted in functionalized pyrazoles with with antibacterial activity.
 Andersen, O.M., Markham, K.R. (2006). Flavonoids: Chemistry, Biochemistry and Applications. USA, Taylor Francis Group, 1256 p.
 Kazakov, A.L., Khilya, V.P., Mezheritskiy, V.V., Litkei, Yu. (1985). Natural and modificated isoflavanoids. Rostov, published University of Rostov, 184 p. (in Russian).
 Legrand, L., Lozac'h, N. (1970). Composґes sulfurґes h`eterocycliques. XXXIX. Action d’amines secondaires aliphatiques sur les aryl-3-thio-1-isocoumarines. Bull. Soc. Chim. France, No. 3, pp. 2227-2232.
 Moskvina, V.S., Shablykina, O.V., Turov, O.V., Ishchenko, V.V., Khilya, V.P. (2012). Study on the reaction products of 2.-carboxydesoxybezoines and their amides with dimethylformamide dimethyl acetal. Dopov. Nac. Akad. Nauk Ukr., No. 11, pp. 144-149 (in Ukrainian).
 Pinto, J.C., Fryer, R.I. (1993). Methylation of 5-phenyl-1,4-benzodiazepin-2-one derivatives with N,N-dimethylformamide-dimethyl acetal J. Heterocyclic Chem., Vol. 30, Iss. 4, pp. 939-943. doi: https://doi.org/10.1002/jhet.5570300416