Antibacterial activity studies of pyrazole derivatives – products of isoflavones recyclization

Chemistry & Chemical Technology


First and Last Name Academic degree E-mail Affiliation
Kateryna Kukushkina No kukushkina.katya [at] Chemical Faculty, Taras Shevchenko National University of Kyiv
Kyiv, Ukraine
Victoriia Moskvina Ph.D. v.moskvina [at] Chemical Faculty, Taras Shevchenko National University of Kyiv
Kyiv , Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First publshed on this website: 01.09.2019 - 19:13

We have established that the recyclization of isocoumarins via 2-hydroxydesoxybenzon-2’-carboxylic acid amides and their subsequent reaction with DMFDMA is an efficient synthetic approach to previously difficult to obtain isoflavones with an amide function. The subsequent recyclization of isoflavones resulted in functionalized pyrazoles with with antibacterial activity.


[1] Andersen, O.M., Markham, K.R. (2006). Flavonoids: Chemistry, Biochemistry and Applications. USA, Taylor Francis Group, 1256 p.

[2] Kazakov, A.L., Khilya, V.P., Mezheritskiy, V.V., Litkei, Yu. (1985). Natural and modificated isoflavanoids. Rostov, published University of Rostov, 184 p. (in Russian).

[3] Legrand, L., Lozac'h, N. (1970). Composґes sulfurґes h`eterocycliques. XXXIX. Action d’amines secondaires aliphatiques sur les aryl-3-thio-1-isocoumarines. Bull. Soc. Chim. France, No. 3, pp. 2227-2232.

[4] Moskvina, V.S., Shablykina, O.V., Turov, O.V., Ishchenko, V.V., Khilya, V.P. (2012). Study on the reaction products of 2.-carboxydesoxybezoines and their amides with dimethylformamide dimethyl acetal.  Dopov. Nac. Akad. Nauk Ukr., No. 11, pp. 144-149 (in Ukrainian).

[5] Pinto, J.C., Fryer, R.I. (1993). Methylation of 5-phenyl-1,4-benzodiazepin-2-one derivatives with N,N-dimethylformamide-dimethyl acetal J. Heterocyclic Chem., Vol. 30, Iss. 4, pp. 939-943. doi:

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Secretary CCT
researcher, secretary

Dear Authors,

Your paper has been accepted!

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Thu, 10/17/2019 - 16:35

Yes, I'm going to take part in conference in person ,  and it would be great to get an invitation letter.

Sun, 10/20/2019 - 20:27
Secretary CCT
researcher, secretary

Dear authors,  add a new version (*doc.) of a paper, please.

Thu, 10/24/2019 - 10:45


Thu, 10/24/2019 - 22:49