Antibacterial activity studies of pyrazole derivatives – products of isoflavones recyclization

Chemistry & Chemical Technology

Authors

First and Last Name Academic degree E-mail Affiliation
Kateryna Kukushkina No kukushkina.katya [at] icloud.com Chemical Faculty, Taras Shevchenko National University of Kyiv
Kyiv, Ukraine
Victoriia Moskvina Ph.D. v.moskvina [at] gmail.com Chemical Faculty, Taras Shevchenko National University of Kyiv
Kyiv , Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First publshed on this website: 01.09.2019 - 19:13
Abstract

We have established that the recyclization of isocoumarins via 2-hydroxydesoxybenzon-2’-carboxylic acid amides and their subsequent reaction with DMFDMA is an efficient synthetic approach to previously difficult to obtain isoflavones with an amide function. The subsequent recyclization of isoflavones resulted in functionalized pyrazoles with with antibacterial activity.

References

[1] Andersen, O.M., Markham, K.R. (2006). Flavonoids: Chemistry, Biochemistry and Applications. USA, Taylor Francis Group, 1256 p.

[2] Kazakov, A.L., Khilya, V.P., Mezheritskiy, V.V., Litkei, Yu. (1985). Natural and modificated isoflavanoids. Rostov, published University of Rostov, 184 p. (in Russian).

[3] Legrand, L., Lozac'h, N. (1970). Composґes sulfurґes h`eterocycliques. XXXIX. Action d’amines secondaires aliphatiques sur les aryl-3-thio-1-isocoumarines. Bull. Soc. Chim. France, No. 3, pp. 2227-2232.

[4] Moskvina, V.S., Shablykina, O.V., Turov, O.V., Ishchenko, V.V., Khilya, V.P. (2012). Study on the reaction products of 2.-carboxydesoxybezoines and their amides with dimethylformamide dimethyl acetal.  Dopov. Nac. Akad. Nauk Ukr., No. 11, pp. 144-149 (in Ukrainian).

[5] Pinto, J.C., Fryer, R.I. (1993). Methylation of 5-phenyl-1,4-benzodiazepin-2-one derivatives with N,N-dimethylformamide-dimethyl acetal J. Heterocyclic Chem., Vol. 30, Iss. 4, pp. 939-943. doi: https://doi.org/10.1002/jhet.5570300416

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Comments

Secretary CCT
researcher, secretary

Dear Authors,

Your paper has been accepted!

We are glad to inform you that your conference paper has been accepted to participate in the 9th International Youth Science Forum «Litteris et Artibus» (November 21-23, 2019, Lviv, Ukraine)! Your paper will be published in digital proceedings with ISSN and DOI on the website https://openreviewhub.org/lea

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Secretary CCT

Thu, 10/17/2019 - 16:35
Kukushkina
researcher

Yes, I'm going to take part in conference in person ,  and it would be great to get an invitation letter.

Sun, 10/20/2019 - 20:27
Secretary CCT
researcher, secretary

Dear authors,  add a new version (*doc.) of a paper, please.

Thu, 10/24/2019 - 10:45
Kukushkina
researcher

 

Thu, 10/24/2019 - 22:49