Poly(ethylene glycol) and Poly(propylene glycol)-Containing Aminofunctional Copolyesters for Biomedical Application

Anna Voronovska1
Andrii Tovarnitskyi1
Oresta Zelenyak1
Myroslava Ranevska1
Anna Stasiuk1
Mariia Ferens1 maria.ferens [at] mail.ru
Nataliia Fihurka1
Ihor Tarnavchyk2 tarnavchyk [at] gmail.com
  1. Organic Chemistry Department, Lviv Polytechnic National University, UKRAINE, Lviv, S. Bandery street 12
  2. Coatings and Polymeric Materials Department, North Dakota State University, USA, 2760, P.O. Box 6050, Fargo, ND 58108-6050
Abstract 

Polyesters (pseudo-poly(amino acids) based on the dicarboxilic amino acids and diols of different molecular weight (polyethylene glycols with polycondensation degree of 2-8) were synthesized using N,N′-dicyclo-hexyl-carbodiimide (DCC) – the activator of carboxyl grous. Also were synthesized the novel amphiphilic polyesterethers based on natural dibasic amino acids including their N-derivatives with controllable
colloidal properties and ionogenic groups of cationic type (amino groups). The complex of properties (amphiphilicity, biodegradability and non-toxic degradation of the products) and the ability to form self-assembled structures in aqueous environment allow to use such polymers to form in vivo delivery systems

References 

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[3] S.Varvarenko, I. Tarnavchyk, A.Voronov, N. Fihurka, I. Dron, N. Nosova, R. Taras, V. Samaryk, S. Voronov. Synthesis and colloidal properties of polyesters based on glutamic acids and glycols of different nature // Chemistry and Chemical Technology. - 2013. - Vol.7, N.2. - P.164-168.