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Synthesis and antibacterial activity of novel 3-substituted 1-(2-methyl-5-nitrophenyl)-5-oxopyrrolidine derivatives

Green chemistry
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 247–248

DOI: https://doi.org/10.23939/cte2019.01.247

Authors

First and Last Name Academic degree E-mail Affiliation
Benas Balandis No benas.balandis [at] ktu.edu Kaunas University of Technology
Kaunas, Lithuania
Kazimieras Anusevičius Ph.D. kazimieras.anusevicius [at] ktu.lt Kaunas University of Technology
Kaunas, Lithuania
Vytautas Mickevičius Sc.D. vytautas.mickevicius [at] ktu.lt Kaunas University of Technology
Kaunas , Lithuania
Maryna Stasevych Ph.D. maryna.v.stasevych [at] gmail.com Lviv Polytechnic National University
Lviv, Ukraine
Volodymyr Novikov Sc.D. volodymyr.p.novikov [at] lpnu.ua Lviv Polytechnic National University
Lviv , Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 15.03.2019 - 13:39
Abstract

The synthesis of novel azole derivatives has been accomplished during chemical transformations of the 1-(2-methyl-5-nitrophenyl)-5-oxopyrrolidine-3-carbohydrazide. The structure of the synthesized compounds was determined by NMR and IR spectroscopies. Most of the synthesized compounds were screened for their antibacterial activity against S. aureus, L. monocytogenes, E. coli, and P. aeruginosa bacteria strains

Keywords
pyrrolidin-2-onesthiazolessulphonylamidesantibacterial activity
References

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[2] S.P. Gasparyan et al., “Synthesis of new derivatives of 5-(3,4-dihydro-2Н-pyrrol-5-yl)-pyrimidine”, Russ. J. Org. Chem., vol. 52, iss. 11, pp. 16461653, Nov. 2016.

[3] V. Mickevičius et al., “Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives”, Molecules, vol. 18, iss. 12, pp. 1500015018, 2013.

[4] N.Y. Wang, et al., “Discovery of Imidazo[2,1-b]thiazole HCV NS4B Inhibitors Exhibiting Synergistic Effect with Other Direct-Acting Antiviral Agents”, J. Med. Chem., vol. 58, iss. 6, pp. 2764–2778, Feb. 2015.

First published Full Text (15.03.2019 - 13:39)
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