Chromatographic studies of extractant residues in the chemical technology of carotenoid production

Green chemistry
Proceedings of the 2nd International Scientific Conference «Chemical Technology and Engineering»: June 24–28, 2019, Lviv: Lviv Polytechnic National University, 2018, pp. 251–254


First and Last Name Academic degree E-mail Affiliation
Volodymyr Gerasimenko Ph.D. gerasim_vlad [at] Ukrainian State University of Chemical Technology
Dnipro, Ukraine
Svitlana Lysytska Ph.D. lsvet050549 [at] National TU Dnipro Polytechnic
Dnipro, Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 15.03.2019 - 15:28

Selected parameters of gas chromatographic analysis, which allow to determine and control the purity of industrial carotene preparations for nutrition and medicine purpose. It has been discovered that undesirable accumulation of chemical reagents in carotenoids in the course of a multi-stage and long- term biomaterial extraction mode requires additional purification from the residues of dangerous extractants.


[1] ICH Harmonized Guideline. Impurities: Guideline for residual solvents Q3C, 2016. [Accessed March 1, 2019].

[2] M.H. Levyn, V.N. Brytsun., R.A. Meleshko, O.N. Tereshchenko, A. A. Humeniuk, Ostanyna N.V. "Sovremennye aspekty normirovanyia y kontrolia profylia prymesei v lekarstvennykh preparatakh", Farmakolohiia ta likarska toksykolohiia, no 4-5 (60), pp. 74-88, 2018.

[3] Vytenberg A.H. Statycheskiy parofazniy hazokhromatohrafycheskiy analyz. "Fyzyko- khimicheskie osnovy oblasti primenenia, Ros. khym. zh. (Zh. Ros. khym. ob-va ym. D.Y. Mendeleeva), vol. XLVII, no 1, pp. 7-22, 2003.

[4] Nykytchenko N.V., Platonov Y.A., Onuchak L.A. Ekstraktsyonno-khromatohrafycheskoe opredelenye kachestva lekarstvennoho rastytelnogo syria "Rastoropsha piatnystaia", Analitika i control, vol. 16, no 2, pp. 169-173, 2012.

Official paper