New Heterocyclic Scaffolds with Thiophene and 1,2,4-triazole Rings
Some chemical modifications of the Gewald 2-amino-thiophenes and 3-aminothiophenes were established. A number of new substituted thienotriazolopyrimidines, thienotriazoles and thiophenyl-triazolothiadiazine were obtained. This study provides new approaches to the construction of substituted 1H-1,2,4-triazoles bearing thiophene core and allows to use data in medical chemistry for further drug discovery.