Molecular Principles of the Spontaneous Mutagenesis in DNA

Ol’ha Brovarets`1,2 o.o.brovarets [at] imbg.org.ua
  1. Department of Molecular and Quantum Biophysics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Ukraine, Kyiv, Akademika Zabolotnoho street 150.
  2. Department of Molecular Biotechnology and Bioinformatics, Institute of High Technologies, Taras Shevchenko National University of Kyiv, Ukraine, Kyiv, Akademika Hlushkova avenue 2-h.
Abstract 

Reported results are crucial for understanding of the microstructural mechanisms of the spontaneous transitions and transversions, since they allow us to explain, from the one side, the origin of the mutagenic tautomers at the separation of the DNA strands before its replication and, from the other side, in what way occurs the adaptation of the incorrect purine·pyrimidine, purine·purine and pyrimidine·pyrimidine wobble pairs to the enzymatically competent sizes in the recognition pocket of the high-fidelity DNA-polymerase. 

Keywords 
spontaneous point mutagenesis
incorporation and replication errors
tautomerisation
pairs of nucleotide bases
enzymatically-competent conformation
hydrogen bond
quantum chemistry
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