Synthesis of New Phosphoric and Amino Acid Derivatives Based on 4,6,4`,6` Hidrazo-Tetrachloro-Bis- 1,3,5-Triazine

Slesarchuk M1
Kudrynetska A1
Synhayevskyy V1
Shakh Y1
Romanenko I1
Bolibrukh H1
Kovalchuk O1
Karhut A1
Polovkovych S1 spolovkovych [at] ukr.net
  1. Department of Technology of biologically active compounds, Pharmacy and Biotechnology,Lviv Polytechnic National University, Ukraine, Lviv, S. Bandery street 12
Abstract 

Interaction optimization techniques and synthesized new heterocyclic derivatives based on hidrazo bis-1,3,5-triazine of aminophosphorus and amino acid fragments. The optimum conditions of flow reactions. Determined and confirmed the structure obtained new heterocyclic triazine systems.

References 

[1] Aamer Saeed, Ghulam Shabir, Iram Batool, "Novel stilbene-triazine symmetrical optical brighteners: synthesis and applications" Journal of Fluorescence., vol. 24. pp.1119-1127, July 2014.

[2] Raval J.P.,Rai A.R. "Synthesis and in vitro antimicrobial activityof N '- (4- (arylamino) - 6 - (pyridine – 2 - ylamino) - 1,3,5 – triazin – 2 - yl) benzohydrazide" International Journal of ChemTech Research., vol.1.pp.616-620, 2009.

[3] Kaminski Z. J., "Triazine-Based Condensing Reagents" Biopolymers (PeptideScience)., vol. 55. pp. 140 – 164,2000.

[4] Polovkovych S.V., [et al.] Synthesis of new 5-acetyl(arylmethyliden)-4-thiazolidones./ Heteroatom Chemistry – 2010. – Vol.21(6). – P.392-396.

[5] Polovkovych S.V., [et al.] Synthesis of New Shiff Bases and Polycyclic Fused Thiopyranothia-zoles Containing 4,6-Dichloro-1,3,5-Triazine Moiety/ Journal of Heterocyclic Chemistry– 2013. – Vol. 50, № 6 – P. 1419-1424.

[6] Saczewski F. Synthesis, structure and anticancer activity of novel 2,4-diamino-1,3,5-triazine derivatives. / Saczewski F., Bulakowska A., Bednarski P. [et al.] // Eur. J. Med. Chem - 2006. - Vol.41. – P.219-225.

[7] Dinku W. Studies on transition metal complexes of herbicidal compounds. II: Transition metal complexes of derivatized 2-chloro-4-ethylamino-6-isopropylaminos- triazine (atrazine) / Dinku W., Megersa N., Raju V. J. T. [et al.] // Bulletin of The Chemical Society of Ethiopia - 2003. – Vol.17(3). – P.35-44.

[8] Srinivas K. Synthesis and antibacterial activity of various substituted s-triazines. / Srinivas K., Srinivas U., Bhanuprakash K. [et al.] // Eur J Med Chem., - 2006. – Vol.41(11). – P.1240-6.