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Synthesis and antibiofilm activity of substituted 1-deazapyrimido[1,2,3-cd]purinium salts

Green chemistry
3rd International Scientific Conference «Chemical Technology and Engineering»: Proceedings – June 21–24th, 2021, Lviv, Ukraine – Lviv: Lviv Polytechnic National University, 2021, pp. 191–192

DOI: https://doi.org/10.23939/cte2021.01.191

Authors

First and Last Name Academic degree E-mail Affiliation
Liubov Muzychka Ph.D. lmuzychka [at] rambler.ru V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
Kyiv, Ukraine
Oksana Muzychka Ph.D. oksimuzya [at] gmail.com V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
Kyiv, Ukraine
Oleg Smolii Sc.D. smoliio [at] ukr.net V. P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine
Kyiv, Ukraine
Iryna Boiko No boikoir.ol [at] gmail.com State Institution Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
Kyiv, Ukraine
Nataliia Hrynchuk No natali72grynchuk [at] gmail.com State Institution Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
Kyiv, Ukraine

I and my co-authors (if any) authorize the use of the Paper in accordance with the Creative Commons CC BY license

First published on this website: 12.04.2021 - 16:56
Abstract

Two examples of new derivatives of 1-deazapyrimido[1,2,3-cd]purine were synthesized by intramolecular cyclization of 7-substituted 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. The results of antimicrobial tests showed that 1-deazapyrimido[1,2,3-cd]purinium salts exhibited a pronounced effect against gram-positive and gram-negative bacteria biofilm.

Keywords
pyrrolo[2-3-d]pyrimidine1-deazapyrimido[1-2-3-cd]purinequaternary saltssynthesisantibiofilm activity
References
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  3. Muzychka, L. V., Yaremchuk, I. O., Verves, E. V., & Smolii, O.B. (2019). Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene. Chemistry of Heterocyclic Compounds, 55(4-5), 397–400. https://doi:10.1007/s10593-019-02471-z
  4. O'Toole, G. A. (2011). Microtiter dish biofilm formation assay. Journal of Visualized Experiments, 47. pii: 2437. https://doi: 10.3791/2437
First published Full Text (12.04.2021 - 16:56)
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