Synthesis and antibiofilm activity of substituted 1-deazapyrimido[1,2,3-cd]purinium salts
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Two examples of new derivatives of 1-deazapyrimido[1,2,3-cd]purine were synthesized by intramolecular cyclization of 7-substituted 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. The results of antimicrobial tests showed that 1-deazapyrimido[1,2,3-cd]purinium salts exhibited a pronounced effect against gram-positive and gram-negative bacteria biofilm.
- Kwaśniewska, D., Chen, Y.-L., & Wieczorek, D. (2020). Biological activity of quaternary ammonium salts and their derivatives. Pathogens, 9(6), 459-471. https://doi:10.3390/pathogens9060459
- Obłąk, E., Futoma-Kołoch, B. & Wieczyńska, A. (2021). Biological activity of quaternary ammonium salts and resistance of microorganisms to these compounds. World Journal Microbiology and Biotechnology, 37, 22. https://doi.org/10.1007/s11274-020-02978-0
- Muzychka, L. V., Yaremchuk, I. O., Verves, E. V., & Smolii, O.B. (2019). Pyrrolo[2,3-d]pyrimidine derivatives in the synthesis of a novel heterocyclic system 2a,5a,7-triazaacenaphthylene. Chemistry of Heterocyclic Compounds, 55(4-5), 397–400. https://doi:10.1007/s10593-019-02471-z
- O'Toole, G. A. (2011). Microtiter dish biofilm formation assay. Journal of Visualized Experiments, 47. pii: 2437. https://doi: 10.3791/2437